Is S-Apamin SP safe in cosmetics?
S-Apamin SP has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
S-Apamin SP
INCI: S-APAMIN SP
S-Apamin SP (CAS Derived from Apamin CAS 24345-16-2 (bee venom peptide); specific "SP" variant may lack a distinct CAS) is a cosmetic cosmetic ingredient functioning as Skin conditioning (anti-inflammatory peptide from bee venom). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
CAS Number
Derived from Apamin CAS 24345-16-2 (bee venom peptide); specific "SP" variant may lack a distinct CAS
View industrial chemical safety profile →
Function
Skin conditioning (anti-inflammatory peptide from bee venom)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated; bee venom-derived peptides used in cosmetics under general safety provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for S-Apamin SP.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for S-Apamin SP — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is S-Apamin SP allowed in the EU?
S-Apamin SP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does S-Apamin SP do in cosmetics?
S-Apamin SP functions as: Skin conditioning (anti-inflammatory peptide from bee venom). It is classified as a cosmetic ingredient in our database. CAS number: Derived from Apamin CAS 24345-16-2 (bee venom peptide); specific "SP" variant may lack a distinct CAS.
Compliance Tools
Check S-Apamin SP compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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