Regulatory Status
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Safety Data
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Expert Verdict
Potent neurotoxin (SK channel blocker); bee venom allergen with anaphylaxis risk; must include allergen warning on label; recommended patch test mandatory before use; low irritation potential at cosmetic concentrations but immune reactions documented
Regulatory Flags
Frequently Asked Questions
Is S-Apamin SP safe in cosmetics?
Potent neurotoxin (SK channel blocker); bee venom allergen with anaphylaxis risk; must include allergen warning on label; recommended patch test mandatory before use; low irritation potential at cosmetic concentrations but immune reactions documented The EU classifies S-Apamin SP as "permitted". Safety rating: MODERATE.
Is S-Apamin SP allowed in the EU?
S-Apamin SP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does S-Apamin SP do in cosmetics?
S-Apamin SP functions as: Skin conditioning (anti-inflammatory peptide from bee venom). It is classified as a cosmetic ingredient in our database. CAS number: Derived from Apamin CAS 24345-16-2 (bee venom peptide); specific "SP" variant may lack a distinct CAS.
What is the Margin of Safety for S-Apamin SP?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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