Salvia Officinalis (Sage) Oil

INCI: SALVIA OFFICINALIS (SAGE) OIL

CAS Number
84082-79-1 (generic); 8022-56-8 (generic)
Function
Fragrance ingredient, skin conditioning agent, tonic, masking agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes GRAS (21 CFR §182.20; FEMA No. 3001). Previously used as OTC astringent active, but FDA ruled insufficient data for that claim (21 CFR §310.545)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Major: thujone content 8–33% (neurotoxic — convulsions at high oral doses); camphor 7–50% variability; irritating/corrosive neat on RhE tissue; α-thujone dominant isomer; reproductive toxicity signals (decreased embryo viability in mice at 0.25% in feed); EMA contraindication in pregnancy for pure oil

⚠️
Concern Level: Moderate

Regulatory Flags

plant-oil fragrance-component

Frequently Asked Questions

Is Salvia Officinalis (Sage) Oil safe in cosmetics?

Major: thujone content 8–33% (neurotoxic — convulsions at high oral doses); camphor 7–50% variability; irritating/corrosive neat on RhE tissue; α-thujone dominant isomer; reproductive toxicity signals (decreased embryo viability in mice at 0.25% in feed); EMA contraindication in pregnancy for pure oil The EU classifies Salvia Officinalis (Sage) Oil as "restricted". Safety rating: GOOD.

Is Salvia Officinalis (Sage) Oil allowed in the EU?

Salvia Officinalis (Sage) Oil EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Salvia Officinalis (Sage) Oil do in cosmetics?

Salvia Officinalis (Sage) Oil functions as: Fragrance ingredient, skin conditioning agent, tonic, masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 84082-79-1 (generic); 8022-56-8 (generic).

What is the Margin of Safety for Salvia Officinalis (Sage) Oil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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