Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Sclareolide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 7.9 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
No dedicated SCCS/CIR monograph. Inhibits 5-lipoxygenase and COX-1 (bioactive — ensure use levels are appropriate). Patent literature describes use for hyperpigmentation treatment at 0.1–40% w/w — higher concentrations require dedicated safety assessment. Formula: C₁₆H₂₆O₂
Regulatory Flags
Frequently Asked Questions
Is Sclareolide safe in cosmetics?
No dedicated SCCS/CIR monograph. Inhibits 5-lipoxygenase and COX-1 (bioactive — ensure use levels are appropriate). Patent literature describes use for hyperpigmentation treatment at 0.1–40% w/w — higher concentrations require dedicated safety assessment. Formula: C₁₆H₂₆O₂ The EU classifies Sclareolide as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Sclareolide allowed in the EU?
Sclareolide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sclareolide do in cosmetics?
Sclareolide functions as: Fragrance (amber/woody fixative), Skin Conditioning (anti-pigmentation, anti-inflammatory). It is classified as a cosmetic ingredient in our database. CAS number: 564-20-5.
What is the Margin of Safety for Sclareolide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sclareolide?
The NOAEL (No Observed Adverse Effect Level) for Sclareolide is 7.9 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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