Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Trade name Clodessine; influences IGF and FGF pathways — no documented adverse effects but the biological activity warrants monitoring at higher concentrations
Frequently Asked Questions
Is sh-Nonapeptide-4 safe in cosmetics?
Trade name Clodessine; influences IGF and FGF pathways — no documented adverse effects but the biological activity warrants monitoring at higher concentrations The EU classifies sh-Nonapeptide-4 as "permitted". Safety rating: GOOD.
Is sh-Nonapeptide-4 allowed in the EU?
sh-Nonapeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Nonapeptide-4 do in cosmetics?
sh-Nonapeptide-4 functions as: Skin Conditioning; Klotho protein fragment — inhibits IGF receptors, stimulates SOD and Catalase production, activates DNA repair. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned in CosIng.
What is the Margin of Safety for sh-Nonapeptide-4?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check sh-Nonapeptide-4 compliance across multiple jurisdictions:
Related Ingredients
Is sh-Nonapeptide-4 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for sh-Nonapeptide-4 in your formulation.