Good Cosmetic Ingredient

sh-Polypeptide-11

INCI: SH-POLYPEPTIDE-11 (FORMER: RH-OLIGOPEPTIDE-13, RH-POLYPEPTIDE-11)

CAS Number
60363-24-4 (Acidic Fibroblast Growth Factor / aFGF)
Function
Skin conditioning (cell signaling / growth factor); stimulates fibroblast proliferation, collagen \& elastin synthesis, wound healing, hair growth promotion
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes No specific FDA monograph; permitted as cosmetic ingredient under general FDCA provisions; not an OTC drug active

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Growth factor ingredient — theoretical concern about stimulating abnormal cell proliferation on compromised skin; no CIR or SCCS formal opinion published; E. coli fermentation source requires rigorous endotoxin/bioburden QC

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Concern Level: Low

Frequently Asked Questions

Is sh-Polypeptide-11 safe in cosmetics?

Growth factor ingredient — theoretical concern about stimulating abnormal cell proliferation on compromised skin; no CIR or SCCS formal opinion published; E. coli fermentation source requires rigorous endotoxin/bioburden QC The EU classifies sh-Polypeptide-11 as "restricted". Safety rating: GOOD.

Is sh-Polypeptide-11 allowed in the EU?

sh-Polypeptide-11 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does sh-Polypeptide-11 do in cosmetics?

sh-Polypeptide-11 functions as: Skin conditioning (cell signaling / growth factor); stimulates fibroblast proliferation, collagen \& elastin synthesis, wound healing, hair growth promotion. It is classified as a cosmetic ingredient in our database. CAS number: 60363-24-4 (Acidic Fibroblast Growth Factor / aFGF).

What is the Margin of Safety for sh-Polypeptide-11?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check sh-Polypeptide-11 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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