Regulatory Status
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Safety Data
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Expert Verdict
IGF-2 is a potent mitogen — theoretical concern about promoting cell proliferation; insulin-like signaling pathway involvement; lipolytic activity may be undesirable in some applications; no Annex restriction
Frequently Asked Questions
Is sh-Polypeptide-31 safe in cosmetics?
IGF-2 is a potent mitogen — theoretical concern about promoting cell proliferation; insulin-like signaling pathway involvement; lipolytic activity may be undesirable in some applications; no Annex restriction The EU classifies sh-Polypeptide-31 as "permitted". Safety rating: GOOD.
Is sh-Polypeptide-31 allowed in the EU?
sh-Polypeptide-31 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Polypeptide-31 do in cosmetics?
sh-Polypeptide-31 functions as: Skin conditioning; recombinant analog of human IGF-2 (Insulin-like Growth Factor 2) — promotes skin density, wrinkle reduction, lipolytic effects, hair growth stimulation. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (CosIng Ref No 86043).
What is the Margin of Safety for sh-Polypeptide-31?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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