Is sh-Polypeptide-9 safe in cosmetics?
sh-Polypeptide-9 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
sh-Polypeptide-9
Also known as: VEGF, Vascular endotheolial growth factor
INCI: SH-POLYPEPTIDE-9
sh-Polypeptide-9 (CAS 127464-60-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning; promotes perifollicular vascularization (hair cycle), cell. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 127464-60-2 →
Function
Skin conditioning; promotes perifollicular vascularization (hair cycle), cell migration, wound healing; key component of BIO-Placenta complexes
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA review; permitted in cosmetics. VEGF claims must stay cosmetic (not therapeutic)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for sh-Polypeptide-9.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Softener and conditioner
Editorial summary
Preliminary editorial summary for sh-Polypeptide-9 — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
VEGF
Vascular endotheolial growth factor
Chemical Function
Softener and conditioner
No specific technical function
Frequently Asked Questions
Is sh-Polypeptide-9 allowed in the EU?
sh-Polypeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Polypeptide-9 do in cosmetics?
sh-Polypeptide-9 functions as: Skin conditioning; promotes perifollicular vascularization (hair cycle), cell migration, wound healing; key component of BIO-Placenta complexes. It is classified as a cosmetic ingredient in our database. CAS number: 127464-60-2.
Compliance Tools
Check sh-Polypeptide-9 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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