Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Silver Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=320 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=247.7 mg/kg bw/day | oral | - | oral | REACH |
| LOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 14 other | oral | rat | oral | REACH |
| LOAEL | 85.8 mg/kg bw/day | oral | - | oral | REACH |
| LOEL | 12 mg/kg bw/day | oral | - | oral | REACH |
Sensitization Profile
Contact sensitization data for Silver Chloride based on clinical patch test studies and IFRA standards.
Source: IVDK; SCCS
Expert Verdict
Restricted to 0.004% AgCl maximum, only as 20% AgCl on TiO2 carrier. Prohibited in children under 3 years and in oral, eye, and lip products.
Regulatory Flags
Frequently Asked Questions
Is Silver Chloride safe in cosmetics?
Restricted to 0.004% AgCl maximum, only as 20% AgCl on TiO2 carrier. Prohibited in children under 3 years and in oral, eye, and lip products. The EU classifies Silver Chloride as "restricted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is Silver Chloride allowed in the EU?
Silver Chloride EU regulatory status: restricted. Maximum allowed concentration: 0.004% (as AgCl) - must be 20% AgCl w/w on TiO2 carrier. This is based on EU Regulation 1223/2009 and its amendments.
What does Silver Chloride do in cosmetics?
Silver Chloride functions as: Preservative (Antimicrobial). It is classified as a Preservative in our database. CAS number: 7783-90-6.
What is the Margin of Safety for Silver Chloride?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Silver Chloride?
The NOAEL (No Observed Adverse Effect Level) for Silver Chloride is >=320 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
Check Silver Chloride compliance across multiple jurisdictions:
Related Ingredients
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