Poor Cosmetic Ingredient NOAEL Data

Sodium Cyanate

INCI: SODIUM CYANATE (NOT AN ESTABLISHED COSMETIC INCI INGREDIENT)

CAS Number
917-61-3
Function
Industrial chemical — NOT a cosmetic ingredient
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Not permitted for cosmetic use — cyanide salt

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Sodium Cyanate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 147 mg/kg bw/day oral rat oral REACH
NOAEL 51 mg/kg bw/day oral monkey oral REACH
NOAEL 300 mg/kg bw/day oral mouse oral REACH
NOAEL 53.5 mg/kg bw/day oral dog oral REACH
NOAEL 30 mg/kg bw/day oral dog oral REACH
LOAEL 150 mg/kg bw/day oral rat oral REACH

Expert Verdict

🚨 PROHIBITED. Classified as toxic (H300+H310+H330 for related cyanides). EU Annex II Entry 111 bans hydrogen cyanide and its salts. Do NOT use in any cosmetic formulation

⚠️
Concern Level: High

Frequently Asked Questions

Is Sodium Cyanate safe in cosmetics?

🚨 PROHIBITED. Classified as toxic (H300+H310+H330 for related cyanides). EU Annex II Entry 111 bans hydrogen cyanide and its salts. Do NOT use in any cosmetic formulation The EU classifies Sodium Cyanate as "prohibited". Safety rating: POOR. 6 toxicological study endpoint(s) are available in our database.

Is Sodium Cyanate allowed in the EU?

Sodium Cyanate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Cyanate do in cosmetics?

Sodium Cyanate functions as: Industrial chemical — NOT a cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 917-61-3.

What is the Margin of Safety for Sodium Cyanate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Cyanate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Cyanate is 147 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.

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