Excellent Cosmetic Ingredient NOAEL Data

Sodium Erythorbate

INCI: SODIUM ERYTHORBATE

CAS Number
6381-77-7
Function
Antioxidant
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; CIR confirmed safe (original 1999, re-reviewed and reconfirmed 2023); also GRAS as food additive

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Sodium Erythorbate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1030 mg/kg bw/day oral mouse Developmental COSMOS_DB
NOAEL 900 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2968 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2968 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Reproductive-developmental COSMOS_DB

Expert Verdict

Stereoisomer of sodium ascorbate; exceptionally well-studied; no significant safety concerns at cosmetic use levels

⚠️
Concern Level: None

Regulatory Flags

fda_food_additive jecfa_safe

Frequently Asked Questions

Is Sodium Erythorbate safe in cosmetics?

Stereoisomer of sodium ascorbate; exceptionally well-studied; no significant safety concerns at cosmetic use levels The EU classifies Sodium Erythorbate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Sodium Erythorbate allowed in the EU?

Sodium Erythorbate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Erythorbate do in cosmetics?

Sodium Erythorbate functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 6381-77-7.

What is the Margin of Safety for Sodium Erythorbate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Erythorbate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Erythorbate is 1030 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Sodium Erythorbate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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