Is Sodium Erythorbate safe in cosmetics?
Sodium Erythorbate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 7 toxicological study endpoint(s) are available in our database.
Sodium Erythorbate
Also known as: Sodium erythorbate (D-erythro-Hex-2-enonic acid, .gamma.-lactone, monosodium salt), Sodium erythorbate (1:1), D-erythro-Hex-2-enonic acid, gamma-lactone, sodium salt (1:1), D-Erythro-hex-2-enonic acid, gamma-lactone, monosodium salt, D-erythro-Hex-2-enonic acid, .gamma.-lactone, sodium salt (1:1) (+5 more)
INCI: SODIUM ERYTHORBATE
Sodium Erythorbate (CAS 6381-77-7) is a cosmetic cosmetic ingredient functioning as Antioxidant. NOAEL 650 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6381-77-7 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
sodium (2R)-2-[(1R)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
InChIKey
PPASLZSBLFJQEF-RKJRWTFHSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR confirmed safe (original 1999, re-reviewed and reconfirmed 2023); also GRAS as food additive
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Erythorbate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Sodium Erythorbate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 900 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1030 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2968 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 3300 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 3435 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =900 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Erythorbate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
self_tanning
{"cas_number": "6381-77-7", "ingredient_class": "other", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_concern": "n…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
SODIUM ISOASCORBATE | 1990 | NOT SPECIFIED | TRS 806-JECFA 37/9 | FAS 28-JECFA 37/29
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Chemical reaction regulator
Dye
Filler
Food preservative
Oxidizing agent
Processing aids not otherwise specified
Surface modifier
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Erythorbate.
Regulatory Flags
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Erythorbate by CAS number or substance name.
Studies
7
Lowest NOAEL
900 mg/kg bw/day
Highest NOAEL
3435 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Sodium erythorbate (D-erythro-Hex-2-enonic acid, .gamma.-lactone, monosodium salt)
Sodium erythorbate (1:1)
D-erythro-Hex-2-enonic acid, gamma-lactone, sodium salt (1:1)
D-Erythro-hex-2-enonic acid, gamma-lactone, monosodium salt
D-erythro-Hex-2-enonic acid, .gamma.-lactone, sodium salt (1:1)
EINECS 228-973-9
Hex-2-enonic acid gamma-lactone, D-erythro-, monosodium salt
Isoascorbic acid sodium salt
Monosodium D-erythro-hex-2-enonic acid gamma-lactone
UNII-BZ468R6XRD
Chemical Function
Antioxidant
Chemical reaction regulator
Biocide
Processing aids not otherwise specified
Surface modifier
Dye
Filler
Food preservative
Oxidizing agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
animal_products
fracking
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
fracking; water
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2309028
Frequently Asked Questions
Is Sodium Erythorbate allowed in the EU?
Sodium Erythorbate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Erythorbate do in cosmetics?
Sodium Erythorbate functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 6381-77-7.
What is the NOAEL for Sodium Erythorbate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Erythorbate is 900 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Is Sodium Erythorbate used outside cosmetics?
Sodium Erythorbate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Erythorbate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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