Excellent Humectant Dermal Penetration

Sodium Hyaluronate

INCI: SODIUM HYALURONATE

CAS Number
9067-32-7
Function
Humectant, skin-conditioning, film-forming, viscosity modifier
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR Expert Panel: safe as used in cosmetics (2009, reaffirmed March 2023). Most used HA form — 4713 formulations per FDA 2023 data.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Sodium Hyaluronate, relevant to systemic exposure and MoS calculations.

Absorption %
0.5-2%
Penetration Level
surface
Penetration Depth
surface/stratum corneum
Molecular Weight
50000-200000 Da
Log P
-9.0
Systemic Absorption
no
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal

Source: SCCS/1512/13

Expert Verdict

The gold-standard cosmetic humectant. Endogenous molecule identical to human skin HA. Binds up to 1000× its weight in water. Backed by decades of clinical evidence for moisturization, anti-aging, barrier repair, and wound healing. No EU or US restrictions. Suitable for all skin types including sensitive and reactive. Highest-frequency cosmetic HA ingredient globally.

⚠️
Concern Level: None

Regulatory Flags

eu_children_restricted

Frequently Asked Questions

Is Sodium Hyaluronate safe in cosmetics?

The gold-standard cosmetic humectant. Endogenous molecule identical to human skin HA. Binds up to 1000× its weight in water. Backed by decades of clinical evidence for moisturization, anti-aging, barrier repair, and wound healing. No EU or US restrictions. Suitable for all skin types including sensitive and reactive. Highest-frequency cosmetic HA ingredient globally. The EU classifies Sodium Hyaluronate as "permitted". Safety rating: EXCELLENT.

Is Sodium Hyaluronate allowed in the EU?

Sodium Hyaluronate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Hyaluronate do in cosmetics?

Sodium Hyaluronate functions as: Humectant, skin-conditioning, film-forming, viscosity modifier. It is classified as a Humectant in our database. CAS number: 9067-32-7.

What is the Margin of Safety for Sodium Hyaluronate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Sodium Hyaluronate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Sodium Hyaluronate Crosspolymer
Excellent
Alanine
Excellent
Erythritol
Excellent
Xylitol
Excellent
Butylene Glycol
Good
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