Sodium Lauroyl Isethionate (SLI)

INCI: SODIUM LAUROYL ISETHIONATE

CAS Number
42926-19-2 (also referenced: 7381-01-3 for alternate forms)
Function
Surfactant, cleansing agent — widely used as primary surfactant in syndet bars and gentle cleansers
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; CIR Amended Safety Assessment concluded isethionate salts are safe as used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Particles in powder form are not respirable (would not enter lungs to appreciable amount) . OSHA HCS classifies the raw material as hazardous for handling purposes (standard for surfactant powders) . Well-tolerated at typical cosmetic use levels

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Concern Level: None

Frequently Asked Questions

Is Sodium Lauroyl Isethionate (SLI) safe in cosmetics?

Particles in powder form are not respirable (would not enter lungs to appreciable amount) . OSHA HCS classifies the raw material as hazardous for handling purposes (standard for surfactant powders) . Well-tolerated at typical cosmetic use levels The EU classifies Sodium Lauroyl Isethionate (SLI) as "permitted". Safety rating: EXCELLENT.

Is Sodium Lauroyl Isethionate (SLI) allowed in the EU?

Sodium Lauroyl Isethionate (SLI) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Lauroyl Isethionate (SLI) do in cosmetics?

Sodium Lauroyl Isethionate (SLI) functions as: Surfactant, cleansing agent — widely used as primary surfactant in syndet bars and gentle cleansers. It is classified as a cosmetic ingredient in our database. CAS number: 42926-19-2 (also referenced: 7381-01-3 for alternate forms).

What is the Margin of Safety for Sodium Lauroyl Isethionate (SLI)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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