Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Sodium Thiocyanate

INCI: SODIUM THIOCYANATE

CAS Number
540-72-7
Function
Reducing agent, antioxidant (used in perming/waving systems)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use with limitations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Sodium Thiocyanate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 20 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance may cause effects on the central nervous system. This may result in excitement and convulsions.
Long-term Exposure Effects
The substance may have effects on the central nervous system and thyroid. This may result in impaired functions and hypothyroidism.

Expert Verdict

Systemic toxicity concern at elevated exposures; thyroid function interference (thiocyanate competes with iodide uptake); concentration limits must be strictly followed

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Concern Level: High

Frequently Asked Questions

Is Sodium Thiocyanate safe in cosmetics?

Systemic toxicity concern at elevated exposures; thyroid function interference (thiocyanate competes with iodide uptake); concentration limits must be strictly followed The EU classifies Sodium Thiocyanate as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Sodium Thiocyanate allowed in the EU?

Sodium Thiocyanate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Thiocyanate do in cosmetics?

Sodium Thiocyanate functions as: Reducing agent, antioxidant (used in perming/waving systems). It is classified as a cosmetic ingredient in our database. CAS number: 540-72-7.

What is the Margin of Safety for Sodium Thiocyanate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Thiocyanate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Thiocyanate is 20 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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