Regulatory Status
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Safety Data
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Expert Verdict
Canada prohibits/restricts spermidine in cosmetics (Cosmetic Ingredient Hotlist) ; polyamines (spermidine, spermine, putrescine) are endogenous cell growth regulators — elevated exogenous levels theoretically could promote abnormal cell proliferation; use level should be carefully justified; emerging anti-aging ingredient with limited long-term topical safety data
Frequently Asked Questions
Is Spermidine HCl safe in cosmetics?
Canada prohibits/restricts spermidine in cosmetics (Cosmetic Ingredient Hotlist) ; polyamines (spermidine, spermine, putrescine) are endogenous cell growth regulators — elevated exogenous levels theoretically could promote abnormal cell proliferation; use level should be carefully justified; emerging anti-aging ingredient with limited long-term topical safety data The EU classifies Spermidine HCl as "permitted". Safety rating: MODERATE.
Is Spermidine HCl allowed in the EU?
Spermidine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Spermidine HCl do in cosmetics?
Spermidine HCl functions as: Skin conditioning, anti-aging (autophagy activator, hair growth stimulant). It is classified as a cosmetic ingredient in our database. CAS number: 334-50-9 (spermidine free base); HCl salt variant used in cosmetics.
What is the Margin of Safety for Spermidine HCl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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