Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Stannous Chloride

INCI: STANNOUS CHLORIDE

CAS Number
7772-99-8
Function
Reducing agent, stabilizer, oral care ingredient (anti-caries in dentifrices)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; also approved as food additive (E 512) which supports its safety profile at low concentrations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Stannous Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1.25 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 0.5 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 50 mg/kg bw/day oral mouse Developmental COSMOS_DB
NOAEL 50 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 50 mg/kg bw/day oral hamster Developmental COSMOS_DB
NOAEL 246 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 41.5 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 60 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 25 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Skin and eye irritant at elevated concentrations; oxidizes readily to stannic (Sn⁴⁺) form; requires pH-controlled formulation; tin accumulation concern at chronic high exposure

⚠️
Concern Level: Moderate

Regulatory Flags

endocrine_disruptor fda_food_additive

Frequently Asked Questions

Is Stannous Chloride safe in cosmetics?

Skin and eye irritant at elevated concentrations; oxidizes readily to stannic (Sn⁴⁺) form; requires pH-controlled formulation; tin accumulation concern at chronic high exposure The EU classifies Stannous Chloride as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Stannous Chloride allowed in the EU?

Stannous Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Stannous Chloride do in cosmetics?

Stannous Chloride functions as: Reducing agent, stabilizer, oral care ingredient (anti-caries in dentifrices). It is classified as a cosmetic ingredient in our database. CAS number: 7772-99-8.

What is the Margin of Safety for Stannous Chloride?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Stannous Chloride?

The NOAEL (No Observed Adverse Effect Level) for Stannous Chloride is 1.25 mg/kg bw/day based on a Chronic study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Stannous Chloride compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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