Good Emollient NOAEL Data SCCS/CIR Reviewed Sensitization Data Dermal Penetration

Stearyl Alcohol

INCI: STEARYL ALCOHOL

CAS Number
36653-82-4
Function
Emollient, emulsion stabilizer
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under Regulation (EC) No 1223/2009

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Stearyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 0.5 % oral dog Subchronic COSMOS_DB
LOAEL 1 % oral rat Subchronic COSMOS_DB

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir Number 3, 1988
Verdict: unknown

Sensitization Profile

Contact sensitization data for Stearyl Alcohol based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
cetyl-group
Reaction Type
contact-dermatitis

Source: IVDK; ESSCA; NACDG

Dermal Penetration Profile

Skin absorption and penetration characteristics of Stearyl Alcohol, relevant to systemic exposure and MoS calculations.

Absorption %
0.1-0.5%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
270.5 Da
Log P
8.0
Systemic Absorption
no
Topical Bioavailability
0.05%
Safety Margin Factor
minimal

Source: CIR

Expert Verdict

Good safety profile with restricted use in EU requiring concentration limit compliance; permitted in US.

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Concern Level: Low

Regulatory Flags

EU Restricted eu_children_restricted ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Stearyl Alcohol safe in cosmetics?

Good safety profile with restricted use in EU requiring concentration limit compliance; permitted in US. The EU classifies Stearyl Alcohol as "restricted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Stearyl Alcohol allowed in the EU?

Stearyl Alcohol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Stearyl Alcohol do in cosmetics?

Stearyl Alcohol functions as: Emollient, emulsion stabilizer. It is classified as a Emollient in our database. CAS number: 36653-82-4.

What is the Margin of Safety for Stearyl Alcohol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Stearyl Alcohol?

The NOAEL (No Observed Adverse Effect Level) for Stearyl Alcohol is 0.5 % based on a Subchronic study via oral route in dog. A total of 2 study endpoints are available. Source: COSMOS_DB.

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