Also known as: 1-Cetanol, 1-Hydroxyhexadecane, Lorol 24, Hexadecyl alcohol, C16 alcohol (+15 more)
INCI: STEARYL ALCOHOL
Stearyl Alcohol (CAS 36653-82-4) is a cosmetic emollient functioning as Emollient, emulsion stabilizer. Reported NOAEL =1822 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: restricted; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 36653-82-4 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Stearyl Alcohol.
Calculate MoS for your specific formulation with the MoS Calculator.
2 study endpoints found for Stearyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1822 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
| NOAEL | =4567 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Contact sensitization data for Stearyl Alcohol based on clinical patch test studies and IFRA standards.
Source: IVDK; ESSCA; NACDG
Skin absorption and penetration characteristics of Stearyl Alcohol, relevant to systemic exposure and MoS calculations.
Source: CIR Expert Panel
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | >1000 mg/kg-day | Rat | oral | short-term | ECHA |
| NOAEL | >=1198 mg/kg-day | Dog | oral | subchronic | ECHA |
| NOAEL | >=1053 mg/kg-day | Dog | oral | subchronic | ECHA |
| NOAEL | =4567 mg/kg-day | Rat | oral | - | ECHA |
| LD50 | >7960 mg/kg | Rat | oral | - | ECHA |
| NOAEL | >1000 mg/kg-day | Rat | oral | short-term | ECHA |
| NOAEL | =1822 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =4567 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | >1000 mg/kg-day | Rat | oral | short-term | ECHA |
| NOAEL | =4567 mg/kg-day | Rat | oral | - | ECHA |
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 1–3 | 10 | CIR Safety Assessment |
| Conditioner | 2–5 | 10 | CIR Safety Assessment |
10 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Stearyl Alcohol.
Public NOAEL study rows linked to Stearyl Alcohol by CAS number or substance name.
Same-CAS public records found in pharmaceutical and food safety data.
Same-CAS rows from the pharmaceutical spoke database.
Same-CAS food additive or FDA GRAS records from the core public database.
Stearyl Alcohol has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Stearyl Alcohol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
Stearyl Alcohol functions as: Emollient, emulsion stabilizer. It is classified as a Emollient in our database. CAS number: 36653-82-4.
The NOAEL (No Observed Adverse Effect Level) for Stearyl Alcohol is =1822 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Stearyl Alcohol also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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