Stephania Cephalantha Root Extract

INCI: STEPHANIA CEPHALANTHA ROOT EXTRACT

CAS Number
Not specifically assigned
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Listed in INCI dictionary (PCPC); no FDA-specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿ”ด CAUTION: Contains cepharanthine and other bisbenzylisoquinoline alkaloids with significant pharmacological activity (anti-inflammatory, immunomodulatory); Stephania species have been associated with aristolochic acid contamination through misidentification/adulteration (Stephania vs. Aristolochia confusion is well-documented in TCM); verify botanical authentication rigorously; aristolochic acids are Annex II prohibited (entry 1395) as known carcinogens

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Stephania Cephalantha Root Extract safe in cosmetics?

๐Ÿ”ด CAUTION: Contains cepharanthine and other bisbenzylisoquinoline alkaloids with significant pharmacological activity (anti-inflammatory, immunomodulatory); Stephania species have been associated with aristolochic acid contamination through misidentification/adulteration (Stephania vs. Aristolochia confusion is well-documented in TCM); verify botanical authentication rigorously; aristolochic acids are Annex II prohibited (entry 1395) as known carcinogens The EU classifies Stephania Cephalantha Root Extract as "permitted". Safety rating: MODERATE.

Is Stephania Cephalantha Root Extract allowed in the EU?

Stephania Cephalantha Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Stephania Cephalantha Root Extract do in cosmetics?

Stephania Cephalantha Root Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned.

What is the Margin of Safety for Stephania Cephalantha Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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