Streptomyces Tsukubaensis Extract

INCI: STREPTOMYCES TSUKUBAENSIS EXTRACT

CAS Number
Not specifically assigned (ferment-derived biological)
Function
Skin conditioning (the organism is the source of tacrolimus/FK-506, but the cosmetic extract is used for skin conditioning/soothing)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically regulated; permitted under general cosmetic ingredient provisions; no FDA monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Source organism produces tacrolimus (immunosuppressant); must verify extract is free of pharmacologically active tacrolimus residues; potential drug-cosmetic boundary issue

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Streptomyces Tsukubaensis Extract safe in cosmetics?

Source organism produces tacrolimus (immunosuppressant); must verify extract is free of pharmacologically active tacrolimus residues; potential drug-cosmetic boundary issue The EU classifies Streptomyces Tsukubaensis Extract as "permitted". Safety rating: MODERATE.

Is Streptomyces Tsukubaensis Extract allowed in the EU?

Streptomyces Tsukubaensis Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Streptomyces Tsukubaensis Extract do in cosmetics?

Streptomyces Tsukubaensis Extract functions as: Skin conditioning (the organism is the source of tacrolimus/FK-506, but the cosmetic extract is used for skin conditioning/soothing). It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned (ferment-derived biological).

What is the Margin of Safety for Streptomyces Tsukubaensis Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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