Is Syringaldehyde safe in cosmetics?
Syringaldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Syringaldehyde
Also known as: BRN 0784514, 3,5-Dimethoxy-4-hydroxybenzene carbonal, EINECS 205-167-5, Syringealdehyde, Syringylaldehyde (+3 more)
INCI: SYRINGALDEHYDE (4-HYDROXY-3,5-DIMETHOXYBENZALDEHYDE)
Syringaldehyde (CAS 134-96-3) is a cosmetic cosmetic ingredient functioning as Fragrance agent, flavor agent; skin conditioning; antioxidant support. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 134-96-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance agent, flavor agent; skin conditioning; antioxidant support
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-hydroxy-3,5-dimethoxybenzaldehyde
InChIKey
KCDXJAYRVLXPFO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; also recognized as a flavor/fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Syringaldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Number
1878
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-HYDROXY-3,5-DIMETHOXY BENZALDEHYDE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/116 | ">FAS 60-JECFA 69/625
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Syringaldehyde.
Regulatory Flags
potential-allergen
fragrance-component
fda_food_additive
Known Synonyms
BRN 0784514
3,5-Dimethoxy-4-hydroxybenzene carbonal
EINECS 205-167-5
Syringealdehyde
Syringylaldehyde
4-Hydroksy-3,5-dwumetoksybenzaldehyd
UNII-2ZR01KTT21
4-hydroxy-3,5-dimethoxy-benzaldehyde
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods
artificial_saliva; detected; emissions; Europe; Toys and children's products
Cleaning products and household care - air freshener; Europe
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SYRINGALDEHYDE
ChEMBL ID
CHEMBL225303
Frequently Asked Questions
Is Syringaldehyde allowed in the EU?
Syringaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Syringaldehyde do in cosmetics?
Syringaldehyde functions as: Fragrance agent, flavor agent; skin conditioning; antioxidant support. It is classified as a cosmetic ingredient in our database. CAS number: 134-96-3.
Is Syringaldehyde used outside cosmetics?
Syringaldehyde also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Syringaldehyde compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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