Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for t-Butyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1080 ppm | 1995 | mouse | inhalation | REACH |
| LOAEL | 1.25 other | oral | rat | oral | REACH |
| NOAEL | 5 other | oral | mouse | oral | REACH |
| NOAEL | 2101 ppm | 1995 | rat | inhalation | REACH |
| NOAEL | 910 ppm | 1995 | mouse | inhalation | REACH |
| LOAEL | 2.5 other | oral | rat | oral | REACH |
| NOAEL | 457 ppm | 1995 | rat | inhalation | REACH |
| LOAEL | 5 other | oral | mouse | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Developmental/reproductive toxicity observed at 1% in animal studies (secondary to maternal toxicity via milk, not in utero); CIR data insufficient for airbrush delivery systems
Regulatory Flags
Frequently Asked Questions
Is t-Butyl Alcohol safe in cosmetics?
Developmental/reproductive toxicity observed at 1% in animal studies (secondary to maternal toxicity via milk, not in utero); CIR data insufficient for airbrush delivery systems The EU classifies t-Butyl Alcohol as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is t-Butyl Alcohol allowed in the EU?
t-Butyl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does t-Butyl Alcohol do in cosmetics?
t-Butyl Alcohol functions as: Denaturant, Fragrance Ingredient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 75-65-0.
What is the Margin of Safety for t-Butyl Alcohol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for t-Butyl Alcohol?
The NOAEL (No Observed Adverse Effect Level) for t-Butyl Alcohol is 1080 ppm based on a inhalation study via 1995 route in mouse. A total of 8 study endpoints are available. Source: REACH.
Is t-Butyl Alcohol classified as hazardous under GHS?
t-Butyl Alcohol carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May be harmful if swallowed May cause drowsiness and dizziness Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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