Good Cosmetic Ingredient NOAEL Data

Citral Dimethyl Acetal

INCI: CITRAL DIMETHYL ACETAL

CAS Number
7549-37-3
Function
Fragrance ingredient with fresh citrus character
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FEMA 2305; JECFA 944; no specific CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Citral Dimethyl Acetal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1500 mg/kg bw/day oral mouse Immunotoxicology COSMOS_DB
dose_tested 1500 mg/kg bw/day oral mouse Immunotoxicology COSMOS_DB

Expert Verdict

Can release free citral under acidic conditions via hydrolysis; formulation pH stability must be verified.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Citral Dimethyl Acetal safe in cosmetics?

Can release free citral under acidic conditions via hydrolysis; formulation pH stability must be verified. The EU classifies Citral Dimethyl Acetal as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Citral Dimethyl Acetal allowed in the EU?

Citral Dimethyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citral Dimethyl Acetal do in cosmetics?

Citral Dimethyl Acetal functions as: Fragrance ingredient with fresh citrus character. It is classified as a cosmetic ingredient in our database. CAS number: 7549-37-3.

What is the Margin of Safety for Citral Dimethyl Acetal?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Citral Dimethyl Acetal?

The NOAEL (No Observed Adverse Effect Level) for Citral Dimethyl Acetal is 1500 mg/kg bw/day based on a Immunotoxicology study via oral route in mouse. A total of 2 study endpoints are available. Source: COSMOS_DB.

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