Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for t-Butyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 120 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Strong sensitizer — occupational allergic contact dermatitis well-documented in nail technicians; unreacted monomer is the primary concern; ensure maximum degree of polymerization; EU regulatory review ongoing for methacrylate monomers in nail products
Regulatory Flags
Frequently Asked Questions
Is t-Butyl Methacrylate safe in cosmetics?
Strong sensitizer — occupational allergic contact dermatitis well-documented in nail technicians; unreacted monomer is the primary concern; ensure maximum degree of polymerization; EU regulatory review ongoing for methacrylate monomers in nail products The EU classifies t-Butyl Methacrylate as "permitted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is t-Butyl Methacrylate allowed in the EU?
t-Butyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does t-Butyl Methacrylate do in cosmetics?
t-Butyl Methacrylate functions as: Film Former (nail products); monomer for polymer synthesis. It is classified as a cosmetic ingredient in our database. CAS number: 585-07-9.
What is the Margin of Safety for t-Butyl Methacrylate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for t-Butyl Methacrylate?
The NOAEL (No Observed Adverse Effect Level) for t-Butyl Methacrylate is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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