Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®)
INCI: TETRAHYDRO-METHYL-PROPYL-PYRAN-4-OLACETATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 600 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Skin sensitizer (NESIL 11,000 μg/cm²); Cramer Class III (higher concern class); not genotoxic; not phototoxic/photoallergenic; not PBT per IFRA
Regulatory Flags
Frequently Asked Questions
Is Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) safe in cosmetics?
Skin sensitizer (NESIL 11,000 μg/cm²); Cramer Class III (higher concern class); not genotoxic; not phototoxic/photoallergenic; not PBT per IFRA The EU classifies Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) allowed in the EU?
Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) do in cosmetics?
Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) functions as: Fragrance – fruity, floral, herbal, clary sage-like. It is classified as a cosmetic ingredient in our database. CAS number: 131766-73-9.
What is the Margin of Safety for Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®)?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-methyl-propyl-pyran-4-olacetate (Clarycet®) is 600 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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