Is Tetramethylolglycoluril safe in cosmetics?
Tetramethylolglycoluril has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Tetramethylolglycoluril
Also known as: Glycoluril, 1,3,4,6-tetrakis(hydroxymethyl)-, Tetramethylol acetylenediurea, Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetrakis(hydroxymethyl)-, 2,4,6,8-Tetrakis(hydroxymethyl)glycoluril, EINECS 226-408-0 (+7 more)
INCI: TETRAMETHYLOLGLYCOLURIL
Tetramethylolglycoluril (CAS 5395-50-6) is a cosmetic cosmetic ingredient functioning as Antimicrobial — helps control the growth of bacteria and fungi; also used as a. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5395-50-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial — helps control the growth of bacteria and fungi; also used as a crosslinking agent in industrial applications
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,3,4,6-tetrakis(hydroxymethyl)-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione
InChIKey
UUGLSEIATNSHRI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted by FDA; permitted for cosmetic use as a preservative/antimicrobial
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetramethylolglycoluril.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for Tetramethylolglycoluril.
Regulatory Flags
potential-allergen
Known Synonyms
Glycoluril, 1,3,4,6-tetrakis(hydroxymethyl)-
Tetramethylol acetylenediurea
Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetrakis(hydroxymethyl)-
2,4,6,8-Tetrakis(hydroxymethyl)glycoluril
EINECS 226-408-0
Fixapret 140
NSC 3319
NSC 67452
Tetrakis(hydroxymethyl)glycoluril
N,N',N'',N'''-Tetrakis(hydroxymethyl)glycoluril
Tetramethylol acetylene diuriene
UNII-3BH30G5P9H
Chemical Function
Biocide
Regulatory Lists
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Tetramethylolglycoluril allowed in the EU?
Tetramethylolglycoluril EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethylolglycoluril do in cosmetics?
Tetramethylolglycoluril functions as: Antimicrobial — helps control the growth of bacteria and fungi; also used as a crosslinking agent in industrial applications. It is classified as a cosmetic ingredient in our database. CAS number: 5395-50-6.
Is Tetramethylolglycoluril used outside cosmetics?
Tetramethylolglycoluril also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tetramethylolglycoluril compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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