Tetramethylolglycoluril

INCI: TETRAMETHYLOLGLYCOLURIL

CAS Number
5395-50-6
Function
Antimicrobial — helps control the growth of bacteria and fungi; also used as a crosslinking agent in industrial applications
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status restricted
US Notes Not specifically restricted by FDA; permitted for cosmetic use as a preservative/antimicrobial

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Formaldehyde donor — releases free formaldehyde over time. Formaldehyde is classified as a sensitizer and carcinogen (Category 1B). Subject to increasing regulatory scrutiny in the EU. Must be labeled "contains formaldehyde" if free formaldehyde exceeds 0.05% in the finished product

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Tetramethylolglycoluril safe in cosmetics?

Formaldehyde donor — releases free formaldehyde over time. Formaldehyde is classified as a sensitizer and carcinogen (Category 1B). Subject to increasing regulatory scrutiny in the EU. Must be labeled "contains formaldehyde" if free formaldehyde exceeds 0.05% in the finished product The EU classifies Tetramethylolglycoluril as "permitted". Safety rating: MODERATE.

Is Tetramethylolglycoluril allowed in the EU?

Tetramethylolglycoluril EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetramethylolglycoluril do in cosmetics?

Tetramethylolglycoluril functions as: Antimicrobial — helps control the growth of bacteria and fungi; also used as a crosslinking agent in industrial applications. It is classified as a cosmetic ingredient in our database. CAS number: 5395-50-6.

What is the Margin of Safety for Tetramethylolglycoluril?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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