Good Cosmetic Ingredient

Tetrapeptide-7

INCI: TETRAPEPTIDE-7 (COMMONLY USED AS PALMITOYL TETRAPEPTIDE-7)

CAS Number
221227-05-0 (as Palmitoyl Tetrapeptide-7, the commercially used form)
Function
Anti-inflammatory (decreases IL-6 secretion); skin conditioning; humectant; reduces inflammation after UVB exposure; stimulates collagen VII, laminin IV and V production
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA monograph; CIR (Cosmetic Ingredient Review) concluded safe as used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Best-characterized ingredient on this list. Palmitoylated form has glycation concern at high concentrations per one reference . Generally considered safe at typical use levels. Avoid spray products without inhalation data per CIR note

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Concern Level: Low

Frequently Asked Questions

Is Tetrapeptide-7 safe in cosmetics?

Best-characterized ingredient on this list. Palmitoylated form has glycation concern at high concentrations per one reference . Generally considered safe at typical use levels. Avoid spray products without inhalation data per CIR note The EU classifies Tetrapeptide-7 as "permitted". Safety rating: GOOD.

Is Tetrapeptide-7 allowed in the EU?

Tetrapeptide-7 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrapeptide-7 do in cosmetics?

Tetrapeptide-7 functions as: Anti-inflammatory (decreases IL-6 secretion); skin conditioning; humectant; reduces inflammation after UVB exposure; stimulates collagen VII, laminin IV and V production. It is classified as a cosmetic ingredient in our database. CAS number: 221227-05-0 (as Palmitoyl Tetrapeptide-7, the commercially used form).

What is the Margin of Safety for Tetrapeptide-7?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Tetrapeptide-7 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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