Tetrapeptide-8

INCI: TETRAPEPTIDE-8

CAS Number
Not publicly assigned (Palmitoyl Tetrapeptide-7, a related derivative, is CAS 221227-05-0)
Function
Skin conditioning; anti-inflammatory peptide class (parent peptide for acylated derivatives used in anti-aging)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically regulated; general cosmetic ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Most commercial use is via acylated forms, not the bare tetrapeptide; ensure you're sourcing the correct derivative

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is Tetrapeptide-8 safe in cosmetics?

Most commercial use is via acylated forms, not the bare tetrapeptide; ensure you're sourcing the correct derivative The EU classifies Tetrapeptide-8 as "permitted". Safety rating: MODERATE.

Is Tetrapeptide-8 allowed in the EU?

Tetrapeptide-8 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrapeptide-8 do in cosmetics?

Tetrapeptide-8 functions as: Skin conditioning; anti-inflammatory peptide class (parent peptide for acylated derivatives used in anti-aging). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (Palmitoyl Tetrapeptide-7, a related derivative, is CAS 221227-05-0).

What is the Margin of Safety for Tetrapeptide-8?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Tetrapeptide-8 in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tetrapeptide-8 in your formulation.