Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Thiamine (Vitamin B1). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1071 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 225 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 75 mg/kg bw/day | oral | mouse | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 1071 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 75 mg/kg bw/day | oral | mouse | Multigeneration Reproductive | COSMOS_DB |
Expert Verdict
Thiamine has a good safety profile and is generally considered safe for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Thiamine (Vitamin B1) safe in cosmetics?
Thiamine has a good safety profile and is generally considered safe for cosmetic use. The EU classifies Thiamine (Vitamin B1) as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Thiamine (Vitamin B1) allowed in the EU?
Thiamine (Vitamin B1) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiamine (Vitamin B1) do in cosmetics?
Thiamine (Vitamin B1) functions as: Preservative. It is classified as a Preservative in our database. CAS number: 59-43-8.
What is the Margin of Safety for Thiamine (Vitamin B1)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thiamine (Vitamin B1)?
The NOAEL (No Observed Adverse Effect Level) for Thiamine (Vitamin B1) is 1071 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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