Toluene-2,5-Diamine Sulfate

INCI: TOLUENE-2,5-DIAMINE SULFATE

CAS Number
615-50-9 (1:1 sulfate); 6369-59-1 (1:x sulfate)
Function
Oxidative hair dye precursor (sulfate salt form)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 3.6%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted as coal tar hair dye with mandatory caution labeling

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Same flags as free base: strong sensitizer, cross-reactive with PPD; o-toluidine impurity control mandatory; SCCS confirmed safe only at reduced concentration vs original 4.0% submission

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Toluene-2,5-Diamine Sulfate safe in cosmetics?

Same flags as free base: strong sensitizer, cross-reactive with PPD; o-toluidine impurity control mandatory; SCCS confirmed safe only at reduced concentration vs original 4.0% submission The EU classifies Toluene-2,5-Diamine Sulfate as "restricted". Safety rating: MODERATE.

Is Toluene-2,5-Diamine Sulfate allowed in the EU?

Toluene-2,5-Diamine Sulfate EU regulatory status: restricted. Maximum allowed concentration: 3.6%. This is based on EU Regulation 1223/2009 and its amendments.

What does Toluene-2,5-Diamine Sulfate do in cosmetics?

Toluene-2,5-Diamine Sulfate functions as: Oxidative hair dye precursor (sulfate salt form). It is classified as a cosmetic ingredient in our database. CAS number: 615-50-9 (1:1 sulfate); 6369-59-1 (1:x sulfate).

What is the Margin of Safety for Toluene-2,5-Diamine Sulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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