Toluene Diisocyanate

INCI: TOLUENE DIISOCYANATE

CAS Number
584-84-9 (2,4-TDI); 91-08-7 (2,6-TDI); 26471-62-5 (mixed isomers)
Function
Not a cosmetic ingredient; industrial polyurethane precursor
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Listed on the Cosmetic Ingredient Hotlist (prohibited)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿšซ CMR substance; respiratory sensitizer; causes occupational asthma; banned in EU and Canadian cosmetics; EPA risk-managed under TSCA

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Concern Level: High

Regulatory Flags

potential-allergen prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Toluene Diisocyanate safe in cosmetics?

๐Ÿšซ CMR substance; respiratory sensitizer; causes occupational asthma; banned in EU and Canadian cosmetics; EPA risk-managed under TSCA The EU classifies Toluene Diisocyanate as "prohibited". Safety rating: POOR.

Is Toluene Diisocyanate allowed in the EU?

Toluene Diisocyanate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Toluene Diisocyanate do in cosmetics?

Toluene Diisocyanate functions as: Not a cosmetic ingredient; industrial polyurethane precursor. It is classified as a cosmetic ingredient in our database. CAS number: 584-84-9 (2,4-TDI); 91-08-7 (2,6-TDI); 26471-62-5 (mixed isomers).

What is the Margin of Safety for Toluene Diisocyanate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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