Is trans-3-Hexenal safe in cosmetics?
trans-3-Hexenal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
trans-3-Hexenal
Also known as: Cis-3-Hexenal
INCI: TRANS-3-HEXENAL / (E)-HEX-3-ENAL
trans-3-Hexenal (CAS 6789-80-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (intense green, leafy, fresh-cut grass aroma). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Fragrance ingredient (intense green, leafy, fresh-cut grass aroma)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(Z)-hex-3-enal
InChIKey
GXANMBISFKBPEX-ARJAWSKDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as fragrance; FEMA GRAS for food use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for trans-3-Hexenal.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
316
Source: WHO/JECFA
JECFA Evaluation
cis-3-HEXENAL | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/68 | FAS 42-JECFA 51/267
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for trans-3-Hexenal — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Cis-3-Hexenal
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CIS-3-HEXENAL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is trans-3-Hexenal allowed in the EU?
trans-3-Hexenal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does trans-3-Hexenal do in cosmetics?
trans-3-Hexenal functions as: Fragrance ingredient (intense green, leafy, fresh-cut grass aroma). It is classified as a cosmetic ingredient in our database. CAS number: 6789-80-6.
Is trans-3-Hexenal used outside cosmetics?
trans-3-Hexenal also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check trans-3-Hexenal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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