Is Triisodecyl Trimellitate safe in cosmetics?
Triisodecyl Trimellitate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Triisodecyl Trimellitate
Also known as: Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester (TK 12627), Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-5-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester, (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(3-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)propanoate), BRN 3579178, EINECS 253-039-2 (+1 more)
INCI: TRIISODECYL TRIMELLITATE
Triisodecyl Trimellitate (CAS 36443-68-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning – emollient, occlusive. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 36443-68-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning – emollient, occlusive
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[2-[2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoyloxy]ethoxy]ethoxy]ethyl 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoate
InChIKey
QSRJVOOOWGXUDY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR concluded safe when formulated to be non-irritating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Triisodecyl Trimellitate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Triisodecyl Trimellitate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
UV stabilizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Triisodecyl Trimellitate.
Known Synonyms
Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester (TK 12627)
Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-5-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester
(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(3-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)propanoate)
BRN 3579178
EINECS 253-039-2
UNII-R24A2HOY7J
Chemical Function
Antioxidant
Regulatory Lists
Europe; plastic_additive
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187604
Frequently Asked Questions
Is Triisodecyl Trimellitate allowed in the EU?
Triisodecyl Trimellitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triisodecyl Trimellitate do in cosmetics?
Triisodecyl Trimellitate functions as: Skin conditioning – emollient, occlusive. It is classified as a cosmetic ingredient in our database. CAS number: 36443-68-2.
Is Triisodecyl Trimellitate used outside cosmetics?
Triisodecyl Trimellitate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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