Triisopropanolamine
INCI: TRIISOPROPANOLAMINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Triisopropanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 288 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | >=7500 ppm | oral | dog | oral | REACH |
| NOAEL | >=3000 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Nitrosamine formation risk — reaction with nitrosating agents produces potentially carcinogenic N-nitrosamines; Annex III compliance mandatory; secondary amine impurity must be controlled; do not combine with nitrosating systems
Frequently Asked Questions
Is Triisopropanolamine safe in cosmetics?
Nitrosamine formation risk — reaction with nitrosating agents produces potentially carcinogenic N-nitrosamines; Annex III compliance mandatory; secondary amine impurity must be controlled; do not combine with nitrosating systems The EU classifies Triisopropanolamine as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Triisopropanolamine allowed in the EU?
Triisopropanolamine EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Triisopropanolamine do in cosmetics?
Triisopropanolamine functions as: Buffering, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 122-20-3.
What is the Margin of Safety for Triisopropanolamine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Triisopropanolamine?
The NOAEL (No Observed Adverse Effect Level) for Triisopropanolamine is 288 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is Triisopropanolamine classified as hazardous under GHS?
Triisopropanolamine carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation Causes skin irritation May cause respiratory irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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