Is Trimethyl-1,3-Pentanediol safe in cosmetics?
Trimethyl-1,3-Pentanediol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Trimethyl-1,3-Pentanediol
Also known as: 4-01-00-02604, BRN 1698098, Caswell No. 893, EINECS 205-619-1, EPA Pesticide Chemical Code 041002 (+1 more)
INCI: TRIMETHYL-1,3-PENTANEDIOL
Trimethyl-1,3-Pentanediol (CAS 144-19-4) is a cosmetic cosmetic ingredient functioning as Solvent (dissolves other substances). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Solvent (dissolves other substances)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2,2,4-trimethylpentane-1,3-diol
InChIKey
JCTXKRPTIMZBJT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; no specific restrictions; also used in industrial applications
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethyl-1,3-Pentanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for Trimethyl-1,3-Pentanediol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
epa_safer_alternative
Known Synonyms
4-01-00-02604
BRN 1698098
Caswell No. 893
EINECS 205-619-1
EPA Pesticide Chemical Code 041002
UNII-WT1X081P0L
Chemical Function
Solvent
Regulatory Lists
artificial_saliva; detected; emissions; Europe; Toys and children's products
CEDI
Indirect additives food contact (10/2018)
SCIL (9/2019)
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184961
Frequently Asked Questions
Is Trimethyl-1,3-Pentanediol allowed in the EU?
Trimethyl-1,3-Pentanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethyl-1,3-Pentanediol do in cosmetics?
Trimethyl-1,3-Pentanediol functions as: Solvent (dissolves other substances). It is classified as a cosmetic ingredient in our database. CAS number: 144-19-4.
Is Trimethyl-1,3-Pentanediol used outside cosmetics?
Trimethyl-1,3-Pentanediol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trimethyl-1,3-Pentanediol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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