Is Trimethylhexamethylene Diisocyanate safe in cosmetics?
Trimethylhexamethylene Diisocyanate has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Trimethylhexamethylene Diisocyanate
INCI: TRIMETHYLHEXAMETHYLENE DIISOCYANATE (MIXTURE OF 2,2,4- AND 2,4,4- ISOMERS)
Trimethylhexamethylene Diisocyanate (CAS 28679-16-5) is a cosmetic cosmetic ingredient functioning as Monomer/crosslinker in polyurethane synthesis — not a direct cosmetic ingredient. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 28679-16-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Trimethylhexamethylene Diisocyanate is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
Function
Monomer/crosslinker in polyurethane synthesis — not a direct cosmetic ingredient
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1,6-diisocyanato-5,6-dimethylheptane
InChIKey
VZXPHDGHQXLXJC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not approved as a direct cosmetic ingredient; residual free isocyanate in polymer-based products must be below detection limits
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylhexamethylene Diisocyanate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylhexamethylene Diisocyanate.
Chemical Function
No specific technical function
Frequently Asked Questions
Is Trimethylhexamethylene Diisocyanate allowed in the EU?
Trimethylhexamethylene Diisocyanate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylhexamethylene Diisocyanate do in cosmetics?
Trimethylhexamethylene Diisocyanate functions as: Monomer/crosslinker in polyurethane synthesis — not a direct cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 28679-16-5.
Is Trimethylhexamethylene Diisocyanate used outside cosmetics?
Trimethylhexamethylene Diisocyanate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Trimethylhexamethylene Diisocyanate have different safety status in cosmetics vs industrial chemicals?
Trimethylhexamethylene Diisocyanate is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check Trimethylhexamethylene Diisocyanate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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