Trimethylhexamethylene Diisocyanate
INCI: TRIMETHYLHEXAMETHYLENE DIISOCYANATE (MIXTURE OF 2,2,4- AND 2,4,4- ISOMERS)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
CRITICAL: Toxic if swallowed, inhaled, or skin-absorbed; GHS Signal Word: DANGER; UN2328; may only exist as fully reacted polyurethane backbone — never as free monomer
Frequently Asked Questions
Is Trimethylhexamethylene Diisocyanate safe in cosmetics?
CRITICAL: Toxic if swallowed, inhaled, or skin-absorbed; GHS Signal Word: DANGER; UN2328; may only exist as fully reacted polyurethane backbone — never as free monomer The EU classifies Trimethylhexamethylene Diisocyanate as "prohibited". Safety rating: POOR.
Is Trimethylhexamethylene Diisocyanate allowed in the EU?
Trimethylhexamethylene Diisocyanate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylhexamethylene Diisocyanate do in cosmetics?
Trimethylhexamethylene Diisocyanate functions as: Monomer/crosslinker in polyurethane synthesis — not a direct cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 28679-16-5.
What is the Margin of Safety for Trimethylhexamethylene Diisocyanate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Trimethylhexamethylene Diisocyanate compliance across multiple jurisdictions:
Related Ingredients
Is Trimethylhexamethylene Diisocyanate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Trimethylhexamethylene Diisocyanate in your formulation.