Good Cosmetic Ingredient NOAEL Data

Trimethylhexanal

INCI: TRIMETHYLHEXANAL

CAS Number
5435-64-3
Function
Perfuming / masking agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use as fragrance ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Trimethylhexanal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.250 mg/kg bw/day oral rat oral REACH

Expert Verdict

Powerful masking agent; may cause mild skin irritation at higher concentrations; primarily used in deodorizers and room fresheners

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Trimethylhexanal safe in cosmetics?

Powerful masking agent; may cause mild skin irritation at higher concentrations; primarily used in deodorizers and room fresheners The EU classifies Trimethylhexanal as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Trimethylhexanal allowed in the EU?

Trimethylhexanal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trimethylhexanal do in cosmetics?

Trimethylhexanal functions as: Perfuming / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 5435-64-3.

What is the Margin of Safety for Trimethylhexanal?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Trimethylhexanal?

The NOAEL (No Observed Adverse Effect Level) for Trimethylhexanal is ca.250 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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