Is Trimethylhexanal safe in cosmetics?
Trimethylhexanal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Trimethylhexanal
Also known as: 4-01-00-03362, BRN 1740882, tert-Butylisopentanal, EINECS 226-603-0, FEMA No. 3524 (+6 more)
INCI: TRIMETHYLHEXANAL
Trimethylhexanal (CAS 5435-64-3) is a cosmetic cosmetic ingredient functioning as Perfuming / masking agent. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 5435-64-3 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming / masking agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,5,5-trimethylhexanal
InChIKey
WTPYRCJDOZVZON-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use as fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylhexanal.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Trimethylhexanal across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Irritating to eyes, respiratory system and skin.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
269
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,5,5-TRIMETHYLHEXANAL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylhexanal.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
4-01-00-03362
BRN 1740882
tert-Butylisopentanal
EINECS 226-603-0
FEMA No. 3524
Hexanal, 3,5,5-trimethl-
Isononylaldehyde
NSC 21482
3,5,5-Trimethylcapronaldehyde
UNII-U62H30BXPJ
Hexanal, 3,5,5-trimethyl-
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185108
Frequently Asked Questions
Is Trimethylhexanal allowed in the EU?
Trimethylhexanal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylhexanal do in cosmetics?
Trimethylhexanal functions as: Perfuming / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 5435-64-3.
Is Trimethylhexanal used outside cosmetics?
Trimethylhexanal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trimethylhexanal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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