Triphenylphosphine
INCI: NOT A RECOGNIZED INCI NAME — THIS IS AN ORGANOPHOSPHORUS LIGAND, NOT A STANDARD COSMETIC INGREDIENT
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Triphenylphosphine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 6 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1 mg/kg bw/day | oral | dog | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rabbit | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
CRITICAL: This is NOT a cosmetic ingredient. GHS hazard: H302, H315, H319, H335. Toxic to aquatic organisms. If you're seeing this in an INCI list, it may be a data error or confusion with Triphenyl Phosphate
Frequently Asked Questions
Is Triphenylphosphine safe in cosmetics?
CRITICAL: This is NOT a cosmetic ingredient. GHS hazard: H302, H315, H319, H335. Toxic to aquatic organisms. If you're seeing this in an INCI list, it may be a data error or confusion with Triphenyl Phosphate The EU classifies Triphenylphosphine as "permitted". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.
Is Triphenylphosphine allowed in the EU?
Triphenylphosphine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triphenylphosphine do in cosmetics?
Triphenylphosphine functions as: Industrial catalyst/ligand in organic synthesis; NOT intended for cosmetic use. It is classified as a cosmetic ingredient in our database. CAS number: 603-35-0.
What is the Margin of Safety for Triphenylphosphine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Triphenylphosphine?
The NOAEL (No Observed Adverse Effect Level) for Triphenylphosphine is 6 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Is Triphenylphosphine classified as hazardous under GHS?
Triphenylphosphine carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed May cause an allergic skin reaction May cause damage to nervous system through prolonged or repeated exposure. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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