Is Triphenylphosphine safe in cosmetics?
Triphenylphosphine has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Triphenylphosphine
Also known as: Triphenyl phosphine, 4-16-00-00951, BRN 0610776, EINECS 210-036-0, Trifenylfosfin (+1 more)
INCI: NOT A RECOGNIZED INCI NAME — THIS IS AN ORGANOPHOSPHORUS LIGAND, NOT A STANDARD COSMETIC INGREDIENT
Triphenylphosphine (CAS 603-35-0) is a cosmetic cosmetic ingredient functioning as Industrial catalyst/ligand in organic synthesis; NOT intended for cosmetic use. NOAEL 1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 603-35-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Triphenylphosphine is classified GHS Danger (H302, H317, H318, H372, H373, H413, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Industrial catalyst/ligand in organic synthesis; NOT intended for cosmetic use
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
triphenylphosphane
InChIKey
RIOQSEWOXXDEQQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not recognized as a cosmetic ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Triphenylphosphine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarnCancerHealth haz
Hazard Statements
Harmful if swallowed May cause an allergic skin reaction May cause damage to nervous system through prolonged or repeated exposure
Short-term Exposure Effects
The substance is mildly irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in impaired functions.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Triphenylphosphine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0700
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Hardener
Heat stabilizer
Softener and conditioner
UV stabilizer
Expert Verdict
Expert safety assessment and concern-level summary for Triphenylphosphine.
Known Synonyms
Triphenyl phosphine
4-16-00-00951
BRN 0610776
EINECS 210-036-0
Trifenylfosfin
UNII-26D26OA393
Chemical Function
Softener and conditioner
Heat stabilizer
Catalyst
UV stabilizer
Hardener
Regulatory Lists
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1448331
Frequently Asked Questions
Is Triphenylphosphine allowed in the EU?
Triphenylphosphine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triphenylphosphine do in cosmetics?
Triphenylphosphine functions as: Industrial catalyst/ligand in organic synthesis; NOT intended for cosmetic use. It is classified as a cosmetic ingredient in our database. CAS number: 603-35-0.
Is Triphenylphosphine classified as hazardous under GHS?
Triphenylphosphine carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed May cause an allergic skin reaction May cause damage to nervous system through prolonged or repeated exposure. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Triphenylphosphine used outside cosmetics?
Triphenylphosphine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Triphenylphosphine have different safety status in cosmetics vs industrial chemicals?
Triphenylphosphine is classified GHS Danger (H302, H317, H318, H372, H373, H413, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Triphenylphosphine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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