Trisodium Phosphate
INCI: TRISODIUM PHOSPHATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Trisodium Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3419 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Corrosive at concentrate — causes severe skin burns and serious eye damage (H314/H318); respiratory irritant (H335); strongly alkaline (pH ~12 at 1%); safe only at low buffering concentrations
Regulatory Flags
Frequently Asked Questions
Is Trisodium Phosphate safe in cosmetics?
Corrosive at concentrate — causes severe skin burns and serious eye damage (H314/H318); respiratory irritant (H335); strongly alkaline (pH ~12 at 1%); safe only at low buffering concentrations The EU classifies Trisodium Phosphate as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Trisodium Phosphate allowed in the EU?
Trisodium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trisodium Phosphate do in cosmetics?
Trisodium Phosphate functions as: Buffering agent; chelating agent; pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 7601-54-9.
What is the Margin of Safety for Trisodium Phosphate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trisodium Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Trisodium Phosphate is 3419 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is Trisodium Phosphate classified as hazardous under GHS?
Trisodium Phosphate carries a GHS signal word of "DANGER". Hazard statements: Causes severe skin burns and eye damage. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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