Tulipalin A

INCI: TULIPALIN A (ฮ‘-METHYLENE-ฮ“-BUTYROLACTONE)

CAS Number
547-65-9
Function
Skin protecting (CosIng listed function)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically regulated; no CIR safety assessment found

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿ”ด Strong contact allergen; causes "tulip fingers" โ€” fissured acropulpitis, hyperpigmentation, onychorrhexis, paronychia; ฮฑ-methylene-ฮณ-butyrolactone is among the most potent sensitizing structural motifs; avoid use in leave-on cosmetics; tulipalin B is a weaker sensitizer by comparison

โš ๏ธ
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Tulipalin A safe in cosmetics?

๐Ÿ”ด Strong contact allergen; causes "tulip fingers" โ€” fissured acropulpitis, hyperpigmentation, onychorrhexis, paronychia; ฮฑ-methylene-ฮณ-butyrolactone is among the most potent sensitizing structural motifs; avoid use in leave-on cosmetics; tulipalin B is a weaker sensitizer by comparison The EU classifies Tulipalin A as "permitted". Safety rating: POOR.

Is Tulipalin A allowed in the EU?

Tulipalin A EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tulipalin A do in cosmetics?

Tulipalin A functions as: Skin protecting (CosIng listed function). It is classified as a cosmetic ingredient in our database. CAS number: 547-65-9.

What is the Margin of Safety for Tulipalin A?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Tulipalin A in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tulipalin A in your formulation.