Good Cosmetic Ingredient NOAEL Data

Vanillyl Butyl Ether

INCI: VANILLYL BUTYL ETHER

CAS Number
82654-98-6
Function
Warming Agent, Fragrance, Hair Conditioning, Oral Care
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics; no specific restrictions; widely used in OTC and cosmetic formulations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Vanillyl Butyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 150 mg/kg bw/day oral rat oral REACH

Expert Verdict

GHS skin sensitizer classification (H317); serious eye irritation (H319); temperature-sensitive โ€” must add below 60ยฐC; dose-dependent warming effect โ€” excessive concentration causes discomfort

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Vanillyl Butyl Ether safe in cosmetics?

GHS skin sensitizer classification (H317); serious eye irritation (H319); temperature-sensitive โ€” must add below 60ยฐC; dose-dependent warming effect โ€” excessive concentration causes discomfort The EU classifies Vanillyl Butyl Ether as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Vanillyl Butyl Ether allowed in the EU?

Vanillyl Butyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Vanillyl Butyl Ether do in cosmetics?

Vanillyl Butyl Ether functions as: Warming Agent, Fragrance, Hair Conditioning, Oral Care. It is classified as a cosmetic ingredient in our database. CAS number: 82654-98-6.

What is the Margin of Safety for Vanillyl Butyl Ether?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Vanillyl Butyl Ether?

The NOAEL (No Observed Adverse Effect Level) for Vanillyl Butyl Ether is 150 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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