Is Vanillyl Butyl Ether safe in cosmetics?
Vanillyl Butyl Ether has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Vanillyl Butyl Ether
Also known as: 4-(Butoxymethyl)-2-methoxyphenol, Butyl vanillyl ether, FEMA No. 3796, UNII-S2ULN37C9R
INCI: VANILLYL BUTYL ETHER
Vanillyl Butyl Ether (CAS 82654-98-6) is a cosmetic cosmetic ingredient functioning as Warming Agent, Fragrance, Hair Conditioning, Oral Care. NOAEL 150 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 82654-98-6 →
Auto-generated CPSR Part A draft with source citations
Function
Warming Agent, Fragrance, Hair Conditioning, Oral Care
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-(butoxymethyl)-2-methoxyphenol
InChIKey
VLDFMKOUUQYFGF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; no specific restrictions; widely used in OTC and cosmetic formulations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vanillyl Butyl Ether.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Vanillyl Butyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =600 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Vanillyl Butyl Ether across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 104 | 0 | 3543 | 3543 | non-sensitizer |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
deodorant
{"cas_number": "82654-98-6", "ingredient_class": "other", "mechanism_of_action": "other", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringency_level": "vari…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
888
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
VANILLYL BUTYL ETHER | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Vanillyl Butyl Ether.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Vanillyl Butyl Ether by CAS number or substance name.
Studies
2
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
600 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
4-(Butoxymethyl)-2-methoxyphenol
Butyl vanillyl ether
FEMA No. 3796
UNII-S2ULN37C9R
Chemical Function
Deodorizer
Softener and conditioner
Fragrance
Regulatory Lists
Europe
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Frequently Asked Questions
Is Vanillyl Butyl Ether allowed in the EU?
Vanillyl Butyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Vanillyl Butyl Ether do in cosmetics?
Vanillyl Butyl Ether functions as: Warming Agent, Fragrance, Hair Conditioning, Oral Care. It is classified as a cosmetic ingredient in our database. CAS number: 82654-98-6.
What is the NOAEL for Vanillyl Butyl Ether?
The NOAEL (No Observed Adverse Effect Level) for Vanillyl Butyl Ether is =150 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Vanillyl Butyl Ether used outside cosmetics?
Vanillyl Butyl Ether also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Vanillyl Butyl Ether compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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