Moderate Cosmetic Ingredient NOAEL Data Sensitization Data

ZINC DIBUTYLDITHIOCARBAMATE

CAS Number
136-23-2
Function
Antimicrobial, Antioxidant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Restricted
EU Max Conc. III/24
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for ZINC DIBUTYLDITHIOCARBAMATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10 mg/kg bw/day oral rat oral REACH
NOAEL 41 mg/kg bw/day oral rat oral REACH

Sensitization Profile

Contact sensitization data for ZINC DIBUTYLDITHIOCARBAMATE based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
rubber
EU Allergen Listed
no
Patch Test Positive Rate
1.0%
Cross-reactivity Group
thiuram-carbamate-group
Reaction Type
contact-dermatitis

Source: ESSCA 2019/20; IVDK; NACDG

Expert Verdict

ZINC DIBUTYLDITHIOCARBAMATE is listed in the EU CosIng database with functions: Antimicrobial, Antioxidant It is restricted under EU Cosmetics Regulation. Restriction: III/24.

โš ๏ธ
Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted preservative antioxidant needs-enrichment

Frequently Asked Questions

Is ZINC DIBUTYLDITHIOCARBAMATE safe in cosmetics?

ZINC DIBUTYLDITHIOCARBAMATE is listed in the EU CosIng database with functions: Antimicrobial, Antioxidant It is restricted under EU Cosmetics Regulation. Restriction: III/24. The EU classifies ZINC DIBUTYLDITHIOCARBAMATE as "Restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is ZINC DIBUTYLDITHIOCARBAMATE allowed in the EU?

ZINC DIBUTYLDITHIOCARBAMATE EU regulatory status: Restricted. Maximum allowed concentration: III/24. This is based on EU Regulation 1223/2009 and its amendments.

What does ZINC DIBUTYLDITHIOCARBAMATE do in cosmetics?

ZINC DIBUTYLDITHIOCARBAMATE functions as: Antimicrobial, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 136-23-2.

What is the NOAEL for ZINC DIBUTYLDITHIOCARBAMATE?

The NOAEL (No Observed Adverse Effect Level) for ZINC DIBUTYLDITHIOCARBAMATE is 10 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is ZINC DIBUTYLDITHIOCARBAMATE in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for ZINC DIBUTYLDITHIOCARBAMATE in your formulation.