Is ZINGERONE safe in cosmetics?
ZINGERONE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
ZINGERONE
Also known as: 4-08-00-01866, BRN 2051099, EINECS 204-548-3, FEMA No. 3124, 3-Methoxy-4-hydroxy-benzylacetone (+14 more)
ZINGERONE (CAS 122-48-5) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 122-48-5 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
4-(4-hydroxy-3-methoxyphenyl)butan-2-one
InChIKey
OJYLAHXKWMRDGS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, brightening", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Specialized …
deodorant
{"cas_number": "122-48-5", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "6-10", "odor_reduction_pct": "30-50", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "limited", "microbiome_impact": "selective", "axillary_microbiome_effect": "varies by …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (5)
JECFA Number
730
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-(4-HYDROXY-3-METHOXYPHENYL)ETHYL METHYL KETONE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-HYDROXY-3-METHOXYBENZYLACETONE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
VANILLYLACETONE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ZINGERONE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for ZINGERONE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-08-00-01866
BRN 2051099
EINECS 204-548-3
FEMA No. 3124
3-Methoxy-4-hydroxy-benzylacetone
NSC 15335
(O)-Paradol
Vanillyl acetone
UNII-4MMW850892
(0)-Paradol
(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone
2-(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone
3-Methoxy-4-hydroxybenzylacetone
4-(3-Methoxy-4-hydroxyphenyl)-2-butanone
4-(3-methoxy-4-hydroxyphenyl)butan-2-one
4-Hydroxy-3-methoxybenzylacetone
Gingerone
Vanillylacetone
Zingherone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
consumer_product
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Europe
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ZINGERONE
ChEMBL ID
CHEMBL25894
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ZINGERONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is ZINGERONE allowed in the EU?
ZINGERONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ZINGERONE do in cosmetics?
ZINGERONE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 122-48-5.
Is ZINGERONE used outside cosmetics?
ZINGERONE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check ZINGERONE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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