Good Cosmetic Ingredient NOAEL Data

1-Furfuryl-1H-Pyrrole

INCI: 1-FURFURYL-1H-PYRROLE

CAS Number
1438-94-4
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FEMA GRAS (3284); not specifically restricted by FDA for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 1-Furfuryl-1H-Pyrrole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 11.2 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 11.2 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Furan-containing heterocycle with acceptable RIFM assessment outcome for cosmetic use.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 1-Furfuryl-1H-Pyrrole safe in cosmetics?

Furan-containing heterocycle with acceptable RIFM assessment outcome for cosmetic use. The EU classifies 1-Furfuryl-1H-Pyrrole as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is 1-Furfuryl-1H-Pyrrole allowed in the EU?

1-Furfuryl-1H-Pyrrole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 1-Furfuryl-1H-Pyrrole do in cosmetics?

1-Furfuryl-1H-Pyrrole functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1438-94-4.

What is the Margin of Safety for 1-Furfuryl-1H-Pyrrole?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 1-Furfuryl-1H-Pyrrole?

The NOAEL (No Observed Adverse Effect Level) for 1-Furfuryl-1H-Pyrrole is 11.2 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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