Is 1-Furfuryl-1H-Pyrrole safe in cosmetics?
1-Furfuryl-1H-Pyrrole has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
1-Furfuryl-1H-Pyrrole
Also known as: 1H-Pyrrole, 1-(2-furanylmethyl)-, 5-20-05-00033, BRN 0118476, EINECS 215-876-1, FEMA No. 3284 (+6 more)
INCI: 1-FURFURYL-1H-PYRROLE
1-Furfuryl-1H-Pyrrole (CAS 1438-94-4) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 25 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
Function
Perfuming
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS (3284); not specifically restricted by FDA for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1-Furfuryl-1H-Pyrrole.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 1-Furfuryl-1H-Pyrrole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 11.2 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 1-Furfuryl-1H-Pyrrole across SCCS product categories, with measured dermal absorption where available.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for 1-Furfuryl-1H-Pyrrole — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 1-Furfuryl-1H-Pyrrole by CAS number or substance name.
Studies
1
Lowest NOAEL
11.2 mg/kg bw/day
Highest NOAEL
11.2 mg/kg bw/day
COSMOS DB
Known Synonyms
1H-Pyrrole, 1-(2-furanylmethyl)-
5-20-05-00033
BRN 0118476
EINECS 215-876-1
FEMA No. 3284
1-(2-Furanylmethyl)-1H-pyrrole
N-Furfuryl pyrrole
N-Furfurylpyrrole
N-(2-Furfuryl)pyrrole
1-(2-Furfuryl)pyrrole
UNII-15HF30X204
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187231
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
N-FURFURYLPYRROLE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 1-Furfuryl-1H-Pyrrole allowed in the EU?
1-Furfuryl-1H-Pyrrole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1-Furfuryl-1H-Pyrrole do in cosmetics?
1-Furfuryl-1H-Pyrrole functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1438-94-4.
What is the NOAEL for 1-Furfuryl-1H-Pyrrole?
The NOAEL (No Observed Adverse Effect Level) for 1-Furfuryl-1H-Pyrrole is 11.2 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS DB.
Is 1-Furfuryl-1H-Pyrrole used outside cosmetics?
1-Furfuryl-1H-Pyrrole also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1-Furfuryl-1H-Pyrrole compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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