Moderate Cosmetic Ingredient

1,3-Bis-(2,4-Diaminophenoxy)Propane

INCI: 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE

CAS Number
81892-72-0 (free base); 74918-21-1 (tetrahydrochloride salt)
Function
Oxidative and non-oxidative hair dye (Colipa A079)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 2.0%
🇺🇸 US Status permitted
US Notes Permitted for use in hair dyes under FDA coal-tar hair dye exemption (21 USC §361(a)) with caution labeling

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mutagenicity concerns flagged in initial submissions; mandatory warning label in EU; not to be used with nitrosating agents

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Concern Level: Moderate

Frequently Asked Questions

Is 1,3-Bis-(2,4-Diaminophenoxy)Propane safe in cosmetics?

Mutagenicity concerns flagged in initial submissions; mandatory warning label in EU; not to be used with nitrosating agents The EU classifies 1,3-Bis-(2,4-Diaminophenoxy)Propane as "prohibited". Safety rating: MODERATE.

Is 1,3-Bis-(2,4-Diaminophenoxy)Propane allowed in the EU?

1,3-Bis-(2,4-Diaminophenoxy)Propane EU regulatory status: prohibited. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does 1,3-Bis-(2,4-Diaminophenoxy)Propane do in cosmetics?

1,3-Bis-(2,4-Diaminophenoxy)Propane functions as: Oxidative and non-oxidative hair dye (Colipa A079). It is classified as a cosmetic ingredient in our database. CAS number: 81892-72-0 (free base); 74918-21-1 (tetrahydrochloride salt).

What is the Margin of Safety for 1,3-Bis-(2,4-Diaminophenoxy)Propane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 1,3-Bis-(2,4-Diaminophenoxy)Propane compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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