Poor Cosmetic Ingredient

1,3-Bis-(Isocyanatomethyl) Cyclohexane

INCI: 1,3-BIS-(ISOCYANATOMETHYL) CYCLOHEXANE

CAS Number
38661-72-2
Function
Monomer / cross-linking agent used in polyurethane-based nail and film-forming products
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA cosmetic restriction; OSHA workplace exposure limits apply

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS hazards include H302 (harmful swallowed), H312 (harmful dermal), H314/H315 (skin burns/irritation), H317 (allergic skin reaction), H318 (serious eye damage). Must be fully reacted before consumer contact as free monomer in finished products poses serious safety concerns.

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Concern Level: High

Frequently Asked Questions

Is 1,3-Bis-(Isocyanatomethyl) Cyclohexane safe in cosmetics?

GHS hazards include H302 (harmful swallowed), H312 (harmful dermal), H314/H315 (skin burns/irritation), H317 (allergic skin reaction), H318 (serious eye damage). Must be fully reacted before consumer contact as free monomer in finished products poses serious safety concerns. The EU classifies 1,3-Bis-(Isocyanatomethyl) Cyclohexane as "permitted". Safety rating: POOR.

Is 1,3-Bis-(Isocyanatomethyl) Cyclohexane allowed in the EU?

1,3-Bis-(Isocyanatomethyl) Cyclohexane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 1,3-Bis-(Isocyanatomethyl) Cyclohexane do in cosmetics?

1,3-Bis-(Isocyanatomethyl) Cyclohexane functions as: Monomer / cross-linking agent used in polyurethane-based nail and film-forming products. It is classified as a cosmetic ingredient in our database. CAS number: 38661-72-2.

What is the Margin of Safety for 1,3-Bis-(Isocyanatomethyl) Cyclohexane?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 1,3-Bis-(Isocyanatomethyl) Cyclohexane compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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