Moderate Cosmetic Ingredient NOAEL Data

4-Ethylphenol

INCI: 4-ETHYLPHENOL

CAS Number
123-07-9
Function
Fragrance (declared as PARFUM)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for 4-Ethylphenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 342 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 342 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 100 mg/kg bw/day oral rat oral REACH

Expert Verdict

Phenol derivative with potential skin irritant and corrosive effects at higher concentrations; weak estrogenic activity observed in screening assays; IFRA-regulated with category-specific limits.

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Concern Level: Moderate

Regulatory Flags

fragrance-component endocrine_disruptor ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 4-Ethylphenol safe in cosmetics?

Phenol derivative with potential skin irritant and corrosive effects at higher concentrations; weak estrogenic activity observed in screening assays; IFRA-regulated with category-specific limits. The EU classifies 4-Ethylphenol as "permitted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.

Is 4-Ethylphenol allowed in the EU?

4-Ethylphenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Ethylphenol do in cosmetics?

4-Ethylphenol functions as: Fragrance (declared as PARFUM). It is classified as a cosmetic ingredient in our database. CAS number: 123-07-9.

What is the Margin of Safety for 4-Ethylphenol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 4-Ethylphenol?

The NOAEL (No Observed Adverse Effect Level) for 4-Ethylphenol is 342 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check 4-Ethylphenol compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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