Is 4-Ethylphenol safe in cosmetics?
4-Ethylphenol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
4-Ethylphenol
Also known as: 4-06-00-03020, BRN 1363317, EINECS 204-598-6, FEMA No. 3156, 1-Hydroxy-4-ethylbenzene (+5 more)
INCI: 4-ETHYLPHENOL
4-Ethylphenol (CAS 123-07-9) is a cosmetic cosmetic ingredient functioning as Fragrance (declared as PARFUM). NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 123-07-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-Ethylphenol is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance (declared as PARFUM)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Ethylphenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 4-Ethylphenol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 122.2
Log Kow: 2.47
Log Kp: -1.4627838567197358
Log Jmax: -5.85
Source: Roberts_Cheruvu_Mendeley_2022
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Processing aids not otherwise specified
Surface modifier
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-Ethylphenol.
Regulatory Flags
fragrance-component
endocrine_disruptor
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-Ethylphenol by CAS number or substance name.
Studies
6
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-06-00-03020
BRN 1363317
EINECS 204-598-6
FEMA No. 3156
1-Hydroxy-4-ethylbenzene
4-Hydroxyethylbenzene
Hydroxyphenylethane, p-
4-Hydroxyphenylethane
para-Ethylphenol
UNII-AGG7E6G0ZC
Chemical Function
Fragrance
Flavouring and nutrient
Processing aids not otherwise specified
Surface modifier
Regulatory Lists
detected; MN Chemical Screening; surface_water
detected; MN Chemical Screening; surface_water
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL108475
Frequently Asked Questions
Is 4-Ethylphenol allowed in the EU?
4-Ethylphenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Ethylphenol do in cosmetics?
4-Ethylphenol functions as: Fragrance (declared as PARFUM). It is classified as a cosmetic ingredient in our database. CAS number: 123-07-9.
Is 4-Ethylphenol used outside cosmetics?
4-Ethylphenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-Ethylphenol have different safety status in cosmetics vs industrial chemicals?
4-Ethylphenol is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 4-Ethylphenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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