2-Ethyl-3-Methylpyrazine
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 2-Ethyl-3-Methylpyrazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Fragrance ingredient with low absorption and sensitization; UV absorption between 290–330 nm warrants photoallergenicity assessment. Genotoxicity studies negative (Ames, BlueScreen). Not PBT. IFRA 51st Amendment: no restriction.
Regulatory Flags
Frequently Asked Questions
Is 2-Ethyl-3-Methylpyrazine safe in cosmetics?
Fragrance ingredient with low absorption and sensitization; UV absorption between 290–330 nm warrants photoallergenicity assessment. Genotoxicity studies negative (Ames, BlueScreen). Not PBT. IFRA 51st Amendment: no restriction. The EU classifies 2-Ethyl-3-Methylpyrazine as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is 2-Ethyl-3-Methylpyrazine allowed in the EU?
2-Ethyl-3-Methylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethyl-3-Methylpyrazine do in cosmetics?
2-Ethyl-3-Methylpyrazine functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 15707-23-0.
What is the Margin of Safety for 2-Ethyl-3-Methylpyrazine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Ethyl-3-Methylpyrazine?
The NOAEL (No Observed Adverse Effect Level) for 2-Ethyl-3-Methylpyrazine is 5 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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