Is 2-Hexanol safe in cosmetics?
2-Hexanol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
2-Hexanol
Also known as: DL-Hexan-2-ol, 2-Hydroxyhexane, (+/-)-2-Hexanol, (+/-)-1-Methyl-1-pentanol, NSC 3706 (+1 more)
INCI: 2-HEXANOL
2-Hexanol (CAS 626-93-7) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming; Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Fragrance / Perfuming; Solvent
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
hexan-2-ol
InChIKey
QNVRIHYSUZMSGM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; FEMA GRAS
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Hexanol.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the skin. The substance may cause effects on the central nervous system.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the nervous system. This may result in peripheral neuropathy.
Routes of Exposure
The substance can be absorbed into the body by inhalation and through the skin.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0488
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Editorial summary
Preliminary editorial summary for 2-Hexanol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
DL-Hexan-2-ol
2-Hydroxyhexane
(+/-)-2-Hexanol
(+/-)-1-Methyl-1-pentanol
NSC 3706
EINECS 210-971-4
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
artificial_saliva; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; emissions; Europe; nondetect; Other direct contact consumer goods
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
2-HEXANOL
ChEMBL ID
CHEMBL45425
Frequently Asked Questions
Is 2-Hexanol allowed in the EU?
2-Hexanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hexanol do in cosmetics?
2-Hexanol functions as: Fragrance / Perfuming; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 626-93-7.
Is 2-Hexanol used outside cosmetics?
2-Hexanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Hexanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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