Is 2-Methyldodecanal safe in cosmetics?
2-Methyldodecanal has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
2-Methyldodecanal
Also known as: Undecanal, 2-methyl-, Aldehyde C-12, M.N.A., Aldehyde M.N.A., Aldehyde C-12 mna, BRN 1758291 (+11 more)
INCI: 2-METHYLDODECANAL
2-Methyldodecanal (CAS 110-41-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with aldehydic, waxy, citrus character. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 110-41-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with aldehydic, waxy, citrus character
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methylundecanal
InChIKey
NFAVNWJJYQAGNB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted with no FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methyldodecanal.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
100%
DPRA Lys %
0%
KeratinoSens IC50
178.023 µM
LLNA EC3
10%
NESIL
2592 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; HPPT: [46] Kligman AM (1971): Report to RIFM, 17 June, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 102 | 0 | 2953 | 2953 | non-sensitizer |
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (4)
JECFA Number
275
Source: WHO/JECFA
JECFA Evaluation
2-METHYLUNDECANAL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: WHO/JECFA
JECFA Evaluation
ALDEHYDE C-12 | 2023 | Not evaluated | JECFA considered that the use of acetaldehyde (No. 80) as a structural analogue in the safety assessment of flavouring substances would require further evaluation. Furthermore, JECFA concluded that the use of acetaldehyde (No. 80) as a flavouring agent requires re-evaluation. JECFA requests that updated exposure data (including both MSDI and SPET values) be p
Source: WHO/JECFA
JECFA Evaluation
METHYL n-NONYL ACETALDEHYDE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-Methyldodecanal.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
Undecanal, 2-methyl-
Aldehyde C-12, M.N.A.
Aldehyde M.N.A.
Aldehyde C-12 mna
BRN 1758291
EINECS 203-765-0
FEMA No. 2749
Methyl n-nonyl acetaldehyde
Methyl nonyl acetic aldehyde
Methyl n-nonyl acetic aldehyde
2-Methylhendecanal
Methylnonylacetaldehyde
Methyl-n-nonylacetaldehyde
Methylnonylacetic aldehyde
NSC 46127
UNII-S94QNS2VY5
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182849
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-METHYLUNDECANAL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 2-Methyldodecanal allowed in the EU?
2-Methyldodecanal EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methyldodecanal do in cosmetics?
2-Methyldodecanal functions as: Fragrance ingredient with aldehydic, waxy, citrus character. It is classified as a cosmetic ingredient in our database. CAS number: 110-41-8.
Is 2-Methyldodecanal used outside cosmetics?
2-Methyldodecanal also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Methyldodecanal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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