Moderate Cosmetic Ingredient NOAEL Data

2-Methyldodecanal

INCI: 2-METHYLDODECANAL

CAS Number
110-41-8
Function
Fragrance ingredient with aldehydic, waxy, citrus character
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted with no FDA cosmetic restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2-Methyldodecanal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 15000 ppm oral rat oral REACH

Expert Verdict

Aldehyde reactivity with Schiff base formation; IFRA restricts maximum use levels; not recommended for damaged or compromised skin.

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Concern Level: Moderate

Regulatory Flags

fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 2-Methyldodecanal safe in cosmetics?

Aldehyde reactivity with Schiff base formation; IFRA restricts maximum use levels; not recommended for damaged or compromised skin. The EU classifies 2-Methyldodecanal as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is 2-Methyldodecanal allowed in the EU?

2-Methyldodecanal EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Methyldodecanal do in cosmetics?

2-Methyldodecanal functions as: Fragrance ingredient with aldehydic, waxy, citrus character. It is classified as a cosmetic ingredient in our database. CAS number: 110-41-8.

What is the Margin of Safety for 2-Methyldodecanal?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Methyldodecanal?

The NOAEL (No Observed Adverse Effect Level) for 2-Methyldodecanal is 15000 ppm based on a oral study via oral route in rat. Source: REACH.

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