Is 2-Methylfuran-3-Thiol safe in cosmetics?
2-Methylfuran-3-Thiol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
2-Methylfuran-3-Thiol
Also known as: 3-Furanthiol, 2-methyl-, EINECS 249-094-7, FEMA No. 3188, 2-Methyl-3-furylmercaptan, 2-Methyl-3-furylthiol (+2 more)
INCI: 2-METHYLFURAN-3-THIOL
2-Methylfuran-3-Thiol (CAS 28588-74-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 28588-74-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Methylfuran-3-Thiol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H318, H330).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methylfuran-3-thiol
InChIKey
RUYNUXHHUVUINQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methylfuran-3-Thiol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Methylfuran-3-Thiol across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1060
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHYL-3-FURANTHIOL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/81 | FAS 50-JECFA 59/299
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2-Methylfuran-3-Thiol.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
3-Furanthiol, 2-methyl-
EINECS 249-094-7
FEMA No. 3188
2-Methyl-3-furylmercaptan
2-Methyl-3-furylthiol
2-Methyl-3-mercaptofuran
UNII-N21RW1N179
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188696
Frequently Asked Questions
Is 2-Methylfuran-3-Thiol allowed in the EU?
2-Methylfuran-3-Thiol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methylfuran-3-Thiol do in cosmetics?
2-Methylfuran-3-Thiol functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 28588-74-1.
Is 2-Methylfuran-3-Thiol used outside cosmetics?
2-Methylfuran-3-Thiol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Methylfuran-3-Thiol have different safety status in cosmetics vs industrial chemicals?
2-Methylfuran-3-Thiol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H318, H330).
Compliance Tools
Check 2-Methylfuran-3-Thiol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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