Moderate Cosmetic Ingredient NOAEL Data

2,4-Diaminophenoxyethanol Sulfate

INCI: 2,4-DIAMINOPHENOXYETHANOL SULFATE

CAS Number
70643-20-8
Function
Oxidative hair dye (primary intermediate/coupler)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 2.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: Covered under the same safety assessment as the HCl salt - safe as used in hair dyes

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2,4-Diaminophenoxyethanol Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 20 mg/kg bw/day oral rat oral REACH

Expert Verdict

Same restrictions as HCl form; concentration caps enforced; professional-only for eyelash applications

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Concern Level: Moderate

Frequently Asked Questions

Is 2,4-Diaminophenoxyethanol Sulfate safe in cosmetics?

Same restrictions as HCl form; concentration caps enforced; professional-only for eyelash applications The EU classifies 2,4-Diaminophenoxyethanol Sulfate as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is 2,4-Diaminophenoxyethanol Sulfate allowed in the EU?

2,4-Diaminophenoxyethanol Sulfate EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,4-Diaminophenoxyethanol Sulfate do in cosmetics?

2,4-Diaminophenoxyethanol Sulfate functions as: Oxidative hair dye (primary intermediate/coupler). It is classified as a cosmetic ingredient in our database. CAS number: 70643-20-8.

What is the Margin of Safety for 2,4-Diaminophenoxyethanol Sulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2,4-Diaminophenoxyethanol Sulfate?

The NOAEL (No Observed Adverse Effect Level) for 2,4-Diaminophenoxyethanol Sulfate is 20 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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