Is 2,4-Diaminophenoxyethanol Sulfate safe in cosmetics?
2,4-Diaminophenoxyethanol Sulfate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
2,4-Diaminophenoxyethanol Sulfate
INCI: 2,4-DIAMINOPHENOXYETHANOL SULFATE
2,4-Diaminophenoxyethanol Sulfate (CAS 70643-20-8) is a cosmetic cosmetic ingredient functioning as Oxidative hair dye (primary intermediate/coupler). NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 2.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 70643-20-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,4-Diaminophenoxyethanol Sulfate is classified GHS Danger (H302, H317, H318, H319, H411, H315, H335) in the chemicals database but is restricted in EU cosmetics at max 2.0%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Oxidative hair dye (primary intermediate/coupler)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2,4-diaminophenoxy)ethanol;sulfuric acid
InChIKey
UUHBEKCQQLDQNG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
2.0%
US US Status
permitted
US Notes
CIR: Covered under the same safety assessment as the HCl salt - safe as used in hair dyes
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,4-Diaminophenoxyethanol Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2,4-Diaminophenoxyethanol Sulfate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 2,4-Diaminophenoxyethanol Sulfate.
Chemical Function
Dye
Regulatory Lists
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the introduction volume of the chemical exceeds 1...
Frequently Asked Questions
Is 2,4-Diaminophenoxyethanol Sulfate allowed in the EU?
2,4-Diaminophenoxyethanol Sulfate EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,4-Diaminophenoxyethanol Sulfate do in cosmetics?
2,4-Diaminophenoxyethanol Sulfate functions as: Oxidative hair dye (primary intermediate/coupler). It is classified as a cosmetic ingredient in our database. CAS number: 70643-20-8.
Is 2,4-Diaminophenoxyethanol Sulfate used outside cosmetics?
2,4-Diaminophenoxyethanol Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,4-Diaminophenoxyethanol Sulfate have different safety status in cosmetics vs industrial chemicals?
2,4-Diaminophenoxyethanol Sulfate is classified GHS Danger (H302, H317, H318, H319, H411, H315, H335) in the chemicals database but is restricted in EU cosmetics at max 2.0%.
Compliance Tools
Check 2,4-Diaminophenoxyethanol Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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